DONOR-RECIPIENT MICROCHIMERISM AND TOLERANCE INDUCTION
نویسندگان
چکیده
منابع مشابه
Microchimerism, dendritic cell progenitors and transplantation tolerance.
The recent discovery of multilineage donor leukocyte microchimerism in allograft recipients up to three decades after organ transplantation implies the migration and survival of donor stem cells within the host. It has been postulated that in chimeric graft recipients, reciprocal modulation of immune responsiveness between donor and recipient leukocytes may lead, eventually, to the induction of...
متن کاملInduction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility complex.
Induction of tolerance to allogeneic MHC antigens has been a goal in the field of transplantation because it would reduce or eliminate the need for generalized immunosuppression. Although encouraging results have been obtained in experimental models by exposing recipient thymus to donor cells before transplantation, donor cells are not typically available at that time, and the donor antigens re...
متن کاملPolyclonal Recipient nTregs Are Superior to Donor or Third-Party Tregs in the Induction of Transplantation Tolerance
Induction of donor-specific tolerance is still considered as the "Holy Grail" in transplantation medicine. The mixed chimerism approach is virtually the only tolerance approach that was successfully translated into the clinical setting. We have previously reported successful induction of chimerism and tolerance using cell therapy with recipient T regulatory cells (Tregs) to avoid cytotoxic reci...
متن کاملInduction of Donor-Specific Tolerance: Is This Achievable?
To the Editor, The final goal of transplant physicians is the induction of donor-specific tolerance (DST), in which the host permanently accepts the graft, but immunity against other antigens is maintained. There have been reports of successful induction of DST in rodent models. However, the majority of studies have focused primarily on the inhibition of costimulatory signals that regulate the ...
متن کاملDonor and recipient leukocytes in organ allografts of recipients with variable donor-specific tolerance: with particular reference to chronic rejection.
We have attributed organ engraftment to clonal exhaustion-deletion of host-versus-graft and graft-versus-host reactions that are reciprocally induced and governed by migratory donor and recipient leukocytes. The so-called donor passenger leukocytes that migrate from the allograft into the recipients have been thoroughly studied (chimerism), but not the donor leukocytes that remain in, or return...
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ژورنال
عنوان ژورنال: Transplantation
سال: 1996
ISSN: 0041-1337
DOI: 10.1097/00007890-199601150-00037